Contrave is an extended-release prescription tablet containing naltrexone hydrochloride and bupropion hydrochloride. Each tablet contains 8mg naltrexone HCl and 90mg bupropion HCl.
It is approved for chronic weight management in adults when used alongside a reduced-calorie diet and increased physical activity. In the U.S. labeling, it is indicated for adults with an initial BMI of 30 kg/m² or greater, or 27 kg/m² or greater when accompanied by at least one weight-related condition.
Contrave should not be marketed as an ordinary over-the-counter slimming supplement. It is a prescription medicine with important contraindications and warnings.
When appropriately prescribed, Contrave may:
The medicine is intended as part of a comprehensive weight-management program, not as a substitute for diet and exercise.
Contrave combines two medicines that act on different pathways involved in appetite and reward.
Naltrexone is an opioid antagonist, while bupropion is an aminoketone antidepressant. Together, they affect brain pathways involved in appetite regulation, food intake and reward-related eating behavior.
The combination is intended to support weight reduction when combined with dietary and physical-activity changes.
Contrave may be prescribed for adults who meet appropriate BMI and weight-related health criteria and for whom a healthcare professional considers the medication suitable.
It is not intended as a cosmetic slimming tablet for people who simply want to lose a few kilograms.
A doctor should evaluate your:
Use Contrave exactly according to your doctor's prescription.
Contrave uses a gradual dose-escalation schedule, rather than immediately starting at the full maintenance dose. The tablets are extended-release and must not be cut, crushed or chewed.
The usual prescribing schedule progresses over several weeks toward a maintenance dose of two tablets twice daily, if tolerated and medically appropriate.
Because Contrave has significant drug interactions and contraindications, do not copy a dosing schedule from an online seller. Your doctor or pharmacist should provide the exact schedule for your prescription.
Do not take Contrave with:
Doctor consultation is strongly required before using Contrave.
Contrave is a prescription medicine and has important safety restrictions.
Contrave is not recommended for weight loss during pregnancy, because weight loss offers no benefit during pregnancy and may harm the fetus.
Bupropion is associated with warnings concerning suicidal thoughts and behavior, particularly in younger people taking antidepressants. Changes in mood or behavior should be discussed promptly with a healthcare professional.
Naltrexone blocks opioid receptors. This means Contrave can interfere with opioid pain medicines and can precipitate opioid withdrawal in people who are physically dependent on opioids.
Tell your doctor about all opioid medicines, cough medicines, painkillers and opioid-containing treatments before starting Contrave.
Common adverse effects can include:
More serious reactions are possible, including seizures, severe psychiatric symptoms, severe allergic reactions and liver-related problems. Seek medical attention for serious or unusual symptoms.
Contrave is used with a reduced-calorie diet and increased physical activity for chronic weight management in certain adults with obesity or overweight plus a weight-related medical condition.
Each extended-release tablet contains 8mg naltrexone HCl and 90mg bupropion HCl.
The standard bottle is commonly 120 extended-release tablets.
Yes. Contrave is a prescription medication and should be used under medical supervision.
No. The branded Contrave formulation uses a specific combination and extended-release formulation. The manufacturer's current FAQ specifically warns that separate naltrexone and bupropion products are not the same formulation approved as Contrave.
Do not do so without medical supervision. Naltrexone blocks opioid receptors and can cause serious problems in people using opioids. Your doctor must review your opioid use before prescribing Contrave.
No. Contrave should not be used for weight loss during pregnancy. Discuss pregnancy or plans for pregnancy with your doctor before starting treatment.
No. It is intended for adults meeting specific weight/BMI criteria and must be evaluated against contraindications and individual medical history.
No, unless specifically directed by a healthcare professional. Taking additional bupropion can increase the risk of adverse effects, including seizures.
Yes. Blood pressure and heart rate can increase, which is one reason medical monitoring is important.
No. It is a treatment that can support chronic weight management while lifestyle measures continue. Long-term weight management requires ongoing lifestyle and medical management.
They should be taken exactly as prescribed and swallowed whole. Do not cut, crush or chew the extended-release tablets.
Pakistani online sellers currently advertise Contrave, with listings showing prices ranging from approximately Rs. 3,500 to Rs. 8,500 depending on the seller and packaging. Availability and authenticity should be verified before purchase.
Check the sealed packaging, batch/lot number, expiry date, manufacturer information and pharmacy source. The current manufacturer FAQ notes that authentic U.S. Contrave tablets are blue, round and marked “NB-890,” although pharmacy dispensing may use plain bottles.
No. It is a prescription pharmaceutical medicine, not an ordinary herbal slimming supplement. It has important contraindications, drug interactions and warnings.
Product safely receive hua aur packaging neat thi